Article
A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.
Proceedings of the National Academy of Sciences of the United States of America - 11 May 1999
Detera-Wadleigh S D, Badner J A, Berrettini W H, Yoshikawa T, Goldin L R, Turner G, Rollins D Y, Moses T, Sanders A R, Karkera J D, Esterling L E, Zeng J, Ferraro T N, Guroff J J, Kazuba D, Maxwell M E, Nurnberger J I, Gershon E S
Abstract excerpt
Bipolar disorder is a severe mental illness characterized by mood swings of elation and depression. Family, twin, and adoption studies suggest a complex genetic etiology that may involve multiple susceptibility genes and an environmental component. To identify chromosomal loci contributing to vulnerability, we have conducted a genome-wide scan on approximately 396 individuals from 22 multiplex pedigrees by using...
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