Article
Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder.
The American journal of psychiatry - 1 Apr 2003
Potash James B, Zandi Peter P, Willour Virginia L, Lan Tsuo-Hung, Huo Yuqing, Avramopoulos Dimitrios, Shugart Yin Y, MacKinnon Dean F, Simpson Sylvia G, McMahon Francis J, DePaulo J Raymond, McInnis Melvin G
Abstract excerpt
OBJECTIVE: Linkage studies of bipolar disorder and schizophrenia have found overlapping evidence for susceptibility genes in four chromosomal regions-10p12-14, 13q32, 18p11.2, and 22q12-13. The authors previously demonstrated familial clustering of psychotic symptoms-defined as hallucinations and/or delusions-in some bipolar disorder pedigrees. In this study they used stratified linkage analysis to test the...
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