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Article

Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.

The Journal of clinical endocrinology and metabolism - 1 Jul 2004

Perticone Francesco, Sciacqua Angela, Scozzafava Angela, Ventura Giorgio, Laratta Emanuela, Pujia Arturo, Federici Massimo, Lauro Renato, Sesti Giorgio

Abstract excerpt

Some cardiovascular risk factors, such as hypertension and insulin resistance, are associated with endothelial dysfunction. Insulin regulates both in vitro and in vivo expression of endothelial nitric oxide synthase (eNOS) via a pathway involving insulin receptor substrate-1 (IRS-1) and phosphatidylinositol-3 kinase. Recently, we found that human endothelial cells obtained from carriers of the Arg(972) IRS-1...

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PMID: 15240653
DOI: 10.1210/jc.2003-032161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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