Article
Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome.
Diabetes - 1 May 2003
Monti Lucilla D, Barlassina Cristina, Citterio Lorena, Galluccio Elena, Berzuini Carlo, Setola Emanuela, Valsecchi Gianpietro, Lucotti Pietro, Pozza Guido, Bernardinelli Luisa, Casari Giorgio, Piatti PierMarco
Abstract excerpt
Endothelial nitric oxide synthase (eNOS) variants were previously demonstrated in cardiovascular disease. To evaluate whether eNOS gene variants are associated with insulin resistance and type 2 diabetes, we evaluated polymorphisms in Exon7 (E298D), intron 18 (IVS18 + 27A-->C), and intron 23 (IVS23 + 10G-->T) in 159 type 2 diabetic patients without macrovascular complications and in 207 healthy control subjects....
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