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Article

The relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease.

Journal of atherosclerosis and thrombosis - 1 Jan 2003

Yoshimura Toru, Hisatomi Akitaka, Kajihara Susumu, Yasutake Tsutomu, Ogawa Youko, Mizuta Toshihiko, Ozaki Iwata, Utsunomiyai Toshinori, Yamamoto Kyosuke

Abstract excerpt

Nitric oxide (NO) regulates endothelial function and is believed to prevent atherogenesis. In endothelial cells, endothelial nitric oxide synthase (eNOS) is expressed constitutively, and regulates NO synthesis. A mutation of the eNOS gene has been associated with the development of coronary artery disease (CAD). The development of CAD is also influenced by insulin resistance, and recent studies suggest that NO...

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Share to Coronary Disease
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Insulin Resistance

Share to Mutation, Missense

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type III

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Source

Identifiers

PMID: 12621164
DOI: 10.5551/jat.10.43

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease.PMID 12621164Read ↗

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