Article
Intima media thickness of carotid arteries is reduced in heterozygous carriers of the Gly972Arg variant in the insulin receptor substrate-1 gene.
European journal of clinical investigation - 1 Feb 2003
Hölzl B, Iglseder B, Stadlmayr A, Hedegger M, Moré E, Reiter R, Sandhofer F, Paulweber B
Abstract excerpt
BACKGROUND: The Gly972Arg mutation in the IRS-1 gene has been found to be associated with insulin resistance and type II diabetes. A recently published study described an association between the Arg allele and an increased risk for coronary artery disease. In the present study we asked whether the presence of the codon 972 mutation in the IRS-1 gene is associated with higher IMT values of the carotid arteries....
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