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Article

Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.

The Journal of clinical endocrinology and metabolism - 1 Jul 2004

Blomhoff Anne, Lie Benedicte A, Myhre Anne G, Kemp E Helen, Weetman Anthony P, Akselsen Hanne E, Huseby Eystein S, Undlien Dag E

Abstract excerpt

The cytotoxic T lymphocyte antigen-4 (CTLA4) gene on chromosome 2q33 encodes a key regulator in the adaptive immune system. The CTLA4 surface molecule is expressed on activated T lymphocytes and involved in down-regulation of the immune response. Previous studies on a possible association between autoimmune Addison's disease and CTLA4 polymorphisms have shown conflicting results. A recent study identified new...

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Source

Identifiers

PMID: 15240634
DOI: 10.1210/jc.2003-031854

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.PMID 15240634Read ↗

CTLA-4 as a genetic determinant in autoimmune Addison's disease.Semantic proximity Read ↗

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.Semantic proximity Read ↗

Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European cohorts.Semantic proximity Read ↗

Association Analysis of the Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) and Autoimmune Regulator-1 (AIRE-1) Genes in Sporadic Autoimmune Addison's DiseaseSemantic proximity Read ↗

Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond.Semantic proximity Read ↗

A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients.Semantic proximity Read ↗

Microsatellite Polymorphism of the MHC Class I Chain-Related (MIC-A and MIC-B) Genes Marks the Risk for Autoimmune Addison's DiseaseSemantic proximity Read ↗

Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune dysregulation.Semantic proximity Read ↗

No evidence of association of CTLA4 polymorphisms with Addison's disease.Semantic proximity Read ↗

Programmed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison’s Disease and Graves’ Disease SusceptibilitySemantic proximity Read ↗

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locusSemantic proximity Read ↗

No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM.Semantic proximity Read ↗

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