Article
No evidence of association of CTLA4 polymorphisms with Addison's disease.
Autoimmunity - 1 Jan 2000
Pérez de Nanclares Guiomar, Martín-Pagola Ainhoa, Ramón Bilbao J, Vázquez Federico, Castaño Luis
Abstract excerpt
BACKGROUND: Addison's disease (AD) is an autoimmune disorder caused by the destruction of the adrenal gland by the lymphocytes in genetically susceptible individuals. The contribution of HLA genes to the genetic risk to AD has been known for a long time; however, non-HLA genetic factors are likely to be required for the development of the disease. Several studies have associated the CD28/CTLA4 region on...
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