Article
A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients.
Clinical endocrinology - 1 Nov 1998
Kemp E H, Ajjan R A, Husebye E S, Peterson P, Uibo R, Imrie H, Pearce S H, Watson P F, Weetman A P
Abstract excerpt
OBJECTIVE: Recent studies have demonstrated an association between a microsatellite polymorphism of the CTLA-4 gene, specifically a 106 base pair allele, and both Graves' disease and autoimmune hypothyroidism. The aim of the present study was to determine whether the same polymorphism of the CTLA-4 gene was associated with autoimmune Addison's disease. DESIGN AND PATIENTS: We analysed a microsatellite...
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