Article
Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal blood.
Biology of reproduction - 1 Jan 2003
Hiendleder Stefan, Zakhartchenko Valeri, Wenigerkind Hendrik, Reichenbach Horst-Dieter, Brüggerhoff Katja, Prelle Katja, Brem Gottfried, Stojkovic Miodrag, Wolf Eckhard
Abstract excerpt
Varying degrees of mitochondrial DNA (mtDNA) heteroplasmy have been observed in nuclear transfer embryos, fetuses, and offspring, but the mechanisms leading to this condition are unknown. We have generated a clone of 12 bovine somatic cell nuclear transfer fetuses, using nuclear donor cells, recipient oocytes, and recipient heifers with defined mtDNA genotypes, to study nuclear-mitochondrial interactions and the...
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