Article
Generation of mtDNA homoplasmic cloned lambs.
Cellular reprogramming - 1 Jun 2010
Lee Joon-Hee, Peters Amy, Fisher Pat, Bowles Emma J, St John Justin C, Campbell Keith H S
Abstract excerpt
Generally in mammals, individual animals contain only maternally inherited mitochondrial DNA (mtDNA), as paternal (sperm)-derived mitochondria are usually eliminated during early development. Somatic cell nuclear transfer (SCNT) bypasses the normal routes of mtDNA inheritance and introduces not only a different nuclear genome into the recipient cytoplast (in general an enucleated oocyte) but also somatic...
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