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Article

Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues

5 Sept 2008

Abstract excerpt

UNLABELLED: BACKGROUND; Mitochondrial DNA (mtDNA) disorders are an important cause of human diseases. In view of the limitations of prenatal diagnosis and preimplantation genetic diagnoses, alternatives such as ooplasmic transfer (OT) and nuclear transfer (NT) have been proposed to prevent the transmission of mtDNA mutations. Both OT and NT are radical in the sense that they do not entail genetic selection, but...

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PMID: 18772267
DOI: 10.1093/humupd/dmn035

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