Article
Mitochondrial DNA genotypes in nuclear transfer-derived cloned sheep.
Nature genetics - 1 Sept 1999
Evans M J, Gurer C, Loike J D, Wilmut I, Schnieke A E, Schon E A
Abstract excerpt
Eukaryotic cells contain two distinct genomes. One is located in the nucleus (nDNA) and is transmitted in a mendelian fashion, whereas the other is located in mitochondria (mtDNA) and is transmitted by maternal inheritance. Cloning of mammals typically has been achieved via nuclear transfer, in which a donor somatic cell is fused by electoporation with a recipient enucleated oocyte. During this whole-cell...
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