Article
Plasma membrane estrogen receptors exist and functions as dimers.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2004
Razandi Mahnaz, Pedram Ali, Merchenthaler Istvan, Greene Geoffrey L, Levin Ellis R
Abstract excerpt
A small pool of estrogen receptors (ERalpha and -beta) localize at the plasma membrane and rapidly signal to affect cellular physiology. Although nuclear ERs function mainly as homodimers, it is unknown whether membrane-localized ER exists or functions with similar requirements. We report that the endogenous ER isoforms at the plasma membrane of breast cancer or endothelial cells exist predominantly as homodimers...
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