ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.

doi:10.1371/journal.pone.0152807

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Article

ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.

PloS one - 1 Jan 2016

Lu Qing, Schnitzler Gavin R, Ueda Kazutaka, Iyer Lakshmanan K, Diomede Olga I, Andrade Tiffany, Karas Richard H

Abstract excerpt

Estrogen promotes the proliferation and migration of vascular endothelial cells (ECs), which likely underlies its ability to accelerate re-endothelialization and reduce adverse remodeling after vascular injury. In previous studies, we have shown that the protective effects of E2 (the active endogenous form of estrogen) in vascular injury require the estrogen receptor alpha (ERα). ERα transduces the effects of...

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Identifiers

PMID: 27035664
DOI: 10.1371/journal.pone.0152807
PMCID: PMC4818104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.