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Article

Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane.

Molecular and cellular biology - 1 Mar 2003

Razandi Mahnaz, Alton Gordon, Pedram Ali, Ghonshani Sanjiv, Webb Paul, Levin Ellis R

Abstract excerpt

Estrogen receptors (ER) have been localized to the cell plasma membrane (PM), where signal transduction mediates some estradiol (E2) actions. However, the precise structural features of ER that result in membrane localization have not been determined. We obtained a partial tryptic peptide/mass spectrometry analysis of membrane mouse ERalpha protein. Based on this, we substituted alanine for the determined serine...

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Identifiers

PMID: 12588983
DOI: 10.1128/MCB.23.5.1633-1646.2003
PMCID: PMC151696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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