Article
Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.
The Journal of pharmacology and experimental therapeutics - 1 Nov 2004
Frazer-Abel Ashley A, Baksh Shairaz, Fosmire Susan P, Willis Derall, Pierce Angela M, Meylemans Heather, Linthicum Darwin S, Burakoff Steven J, Coons Teresa, Bellgrau Donald, Modiano Jaime F
Abstract excerpt
We used primary peripheral blood T cells, a population that exists in G(0) and can be stimulated to enter the cell cycle synchronously, to define more precisely the effects of nicotine on pathways that control cell cycle entry and progression. Our data show that nicotine decreased the ability of T cells to transit through the G(0)/G(1) boundary (acquire competence) and respond to progression signals. These...
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