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Human Immunodeficiency Virus Type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest

11 May 2011

Abstract excerpt

The two major cytopathic factors in human immunodeficiency virus type 1 (HIV-1), the accessory proteins viral infectivity factor (Vif) and viral protein R (Vpr), inhibit cell-cycle progression at the G2 phase of the cell cycle. Although Vpr-induced blockade and the associated T-cell death have been well studied, the molecular mechanism of G2 arrest by Vif remains undefined. To elucidate how Vif induces arrest, we...

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PMID: 21569376
DOI: 10.1186/1743-422x-8-219

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Human Immunodeficiency Virus Type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrestPMID 21569376Read ↗

The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.Semantic proximity Read ↗

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activitySemantic proximity Read ↗

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Effect of HIV-1 Vpr on Cell Cycle RegulatorsSemantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin BSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 InfectionSemantic proximity Read ↗

Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle ArrestSemantic proximity Read ↗

Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycleSemantic proximity Read ↗

Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral ProductionSemantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophages.Semantic proximity Read ↗

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