Article
A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts.
The Journal of biological chemistry - 9 May 2003
Neal Joel W, Clipstone Neil A
Abstract excerpt
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway is best known for its role in T lymphocyte activation. However, it has become increasingly apparent that this signaling pathway is also involved in the regulation of cell growth and development in a wide variety of different tissues and cell types. Here we have investigated the effects of sustained NFATc1 signaling on the growth and...
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