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Article

Targeting the DNA damage response in pediatric malignancies.

Expert review of anticancer therapy - 1 Oct 2022

Gedminas Jenna M, Laetsch Theodore W

Abstract excerpt

INTRODUCTION: High levels of DNA damage and mutations in DNA damage response genes create a high reliance on DNA damage repair in various tumors. This creates a vulnerability for new cancer therapies. Although there is extensive data for the use of these agents in adult tumors, the evaluation of these compounds in the pediatric population remains in the early stages. AREAS COVERED: In this review, we discuss the...

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PMID: 36099180
DOI: 10.1080/14737140.2022.2124970

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