Article
Neoantigen Load, Antigen Presentation Machinery, and Immune Signatures Determine Prognosis in Clear Cell Renal Cell Carcinoma.
Cancer immunology research - 1 May 2016
Matsushita Hirokazu, Sato Yusuke, Karasaki Takahiro, Nakagawa Tohru, Kume Haruki, Ogawa Seishi, Homma Yukio, Kakimi Kazuhiro
Abstract excerpt
Tumors commonly harbor multiple genetic alterations, some of which initiate tumorigenesis. Among these, some tumor-specific somatic mutations resulting in mutated protein have the potential to induce antitumor immune responses. To examine the relevance of the latter to immune responses in the tumor and to patient outcomes, we used datasets of whole-exome and RNA sequencing from 97 clear cell renal cell carcinoma...
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