Article
Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies.
Journal for immunotherapy of cancer - 13 Jul 2018
Tubb Vanessa M, Schrikkema Deborah S, Croft Nathan P, Purcell Anthony W, Linnemann Carsten, Freriks Manon R, Chen Frederick, Long Heather M, Lee Steven P, Bendle Gavin M
Abstract excerpt
Mutation-derived neoantigens represent an important class of tumour-specific, tumour rejection antigens, and are attractive targets for TCR gene therapy of cancer. The majority of such mutations are patient-specific and targeting these requires a fully personalized approach. However, some mutations are found recurrently among cancer patients, and represent potential targets for neoantigen-specific TCR gene...
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