Article
A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans.
Molecular biology of the cell - 1 Sept 2004
Smith Deborah A, Nicholls Susan, Morgan Brian A, Brown Alistair J P, Quinn Janet
Abstract excerpt
Previous work has implicated the Hog1 stress-activated protein kinase (SAPK) in osmotic and oxidative stress responses in the human pathogen Candida albicans. In this study, we have characterized the role of Hog1 in mediating these and other stress responses in C. albicans. We provide evidence that a SAPK-dependent core stress response exists in this pathogen. The Hog1 SAPK is phosphorylated and it accumulates in...
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