Article
Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress.
Eukaryotic cell - 1 Oct 2003
Chauhan Neeraj, Inglis Diane, Roman Elvira, Pla Jesus, Li Dongmei, Calera Jose A, Calderone Richard
Abstract excerpt
Ssk1p of Candida albicans is a putative response regulator protein of the Hog1 two-component signal transduction system. In Saccharomyces cerevisiae, the phosphorylation state of Ssk1p determines whether genes that promote the adaptation of cells to osmotic stress are activated. We have previously shown that C. albicans SSK1 does not complement the ssk1 mutant of S. cerevisiae and that the ssk1 mutant of C....
Topics
- Adaptation, Physiological
- Candida albicans
- Cell Division
- Cell Wall
- Dose-Response Relationship, Drug
- Down-Regulation
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genes, Regulator
- Heat-Shock Response
- Hydrogen Peroxide