Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review.

Pharmacogenomics - 1 Apr 2016

Roy Lilla M, Zur Richard M, Uleryk Elizabeth, Carew Chris, Ito Shinya, Ungar Wendy J

Abstract excerpt

AIM: Thiopurine S-methyltransferase (TPMT) testing is used in patients receiving thiopurines to identify enzyme deficiencies and risk for adverse drug reactions. It is uncertain whether genotyping is superior to phenotyping. The objectives were to conduct a systematic review of TPMT-test performance studies. MATERIALS & METHODS: Electronic and grey literature sources were searched for studies reporting test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Drug-Related Side Effects and Adverse Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Genotype

Share to Methyltransferases

Share to Mutation

Share to Phenotype

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 27020704
DOI: 10.2217/pgs.16.12
PMCID: PMC4931919

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review.PMID 27020704Read ↗

Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy.Semantic proximity Read ↗

Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.Semantic proximity Read ↗

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Semantic proximity Read ↗

Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come.Semantic proximity Read ↗

Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies.Semantic proximity Read ↗

Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

Clinical utility of thiopurine S-methyltransferase genotyping.Semantic proximity Read ↗

Utility of assessing thiopurine S-methyltransferase polymorphisms before azathioprine therapy.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.Semantic proximity Read ↗

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.Semantic proximity Read ↗

Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update.Semantic proximity Read ↗

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.