Article
Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity.
Physiological genomics - 16 Sept 2004
Wansink Derick G, Peters Wilma, Schaafsma Iris, Sutmuller Roger P M, Oerlemans Frank, Adema Gosse J, Wieringa Bé, van der Zee Catharina E E M, Hendriks Wiljan
Abstract excerpt
Mouse PTP-BL is a large, nontransmembrane protein tyrosine phosphatase of unclear physiological function that consists of a KIND domain, a FERM domain, five PDZ domains, and a COOH-terminal catalytic PTP domain. PTP-BL and its human ortholog PTP-BAS have been proposed to play a role in the regulation of microfilament dynamics, cytokinesis, apoptosis, and neurite outgrowth. To investigate the biological function...
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