Article
Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.
The Journal of biological chemistry - 25 Sept 2009
Fuchs Peter, Zörer Michael, Reipert Siegfried, Rezniczek Günther A, Propst Friedrich, Walko Gernot, Fischer Irmgard, Bauer Jan, Leschnik Michael W, Lüscher Bernhard, Thalhammer Johann G, Lassmann Hans, Wiche Gerhard
Abstract excerpt
Cytolinker proteins stabilize cells mechanically, regulate cytoskeleton dynamics, and provide scaffolds for signaling molecules. For plectin, the prototype of these proteins, an unusual diversity of isoforms has been reported, which show distinct expression patterns, subcellular localizations, and functions. Plectin has been shown to have important functions in skin and muscle, but little is known about its role...
Topics
- Animals
- Central Nervous System
- Female
- Gene Targeting
- Genotype
- Immunoblotting
- Immunohistochemistry
- Male
- Mice
- Mice, Inbred C57BL