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Article

Analysis of the desmoplakin gene reveals striking conservation with other members of the plakin family of cytolinkers.

Experimental dermatology - 1 Dec 1999

Green K J, Guy S G, Cserhalmi-Friedman P B, McLean W H, Christiano A M, Wagner R M

Abstract excerpt

Members of the plakin family of cytolinker proteins integrate filaments into cellular networks and anchor these networks to the plasma membrane. Their importance is supported by the existence of cell and tissue fragility disorders caused by mutations in certain family members. In this study, the human gene encoding desmoplakin (DSP) was characterized and its structure compared with the related family members:...

Read the complete abstract on PubMed

Topics

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Share to Conserved Sequence
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

Share to Skin Diseases, Genetic

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Source

Identifiers

PMID: 10597135
DOI: 10.1111/j.1600-0625.1999.tb00304.x

Genes

DSP
EVPL
PPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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