Article
The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors.
Stem cells (Dayton, Ohio) - 1 Feb 2008
Haddad Rima, Pflumio Françoise, Vigon Isabelle, Visentin Géraldine, Auvray Céline, Fichelson Serge, Amsellem Sophie
Abstract excerpt
The HOXB4 homeoprotein is known to promote the expansion of mouse and human hematopoietic stem cells (HSCs) and progenitors of the myeloid lineages. However, the putative involvement of HOXB4 in lymphopoiesis and particularly in the expansion of early lymphoid progenitor cells has remained elusive. Based on the ability of the HOXB4 protein to passively enter hematopoietic cells, our group previously designed a...
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