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Article

HOXB4's road map to stem cell expansion

16 Oct 2007

Abstract excerpt

Homeodomain-containing transcription factors are important regulators of stem cell behavior. HOXB4 mediates expansion of adult and embryo-derived hematopoietic stem cells (HSCs) when expressed ectopically. To define the underlying molecular mechanisms, we performed gene expression profiling in combination with subsequent functional analysis with enriched adult HSCs and embryonic derivatives expressing inducible...

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PMID: 17940039
DOI: 10.1073/pnas.0703082104

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