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Article

Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2004

Milsom Michael D, Woolford Lorna B, Margison Geoffrey P, Humphries R Keith, Fairbairn Leslie J

Abstract excerpt

To attain therapeutic levels of gene-modified hematopoietic stem cells, it may be necessary in the majority of disorders to provide an in vivo selective advantage that facilitates the expansion of their numbers. A popular strategy to achieve in vivo selection has been to employ drug selection while coexpressing a transgene that conveys chemoresistance, such as O6-methylguanine-DNA-methyltransferase (MGMT). An...

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Source

Identifiers

PMID: 15509504
DOI: 10.1016/j.ymthe.2004.07.019

Genes

HOXB4
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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