Article
Aldosterone synthase alleles and cardiovascular phenotype in young adults.
Journal of human hypertension - 1 Dec 2003
Sarzani R, Salvi F, Dessì-Fulgheri P, Catalini R, Mazzara D, Cola G, Siragusa N, Spagnolo D, Ercolani P, Gesuita R, Carle F, Rappelli A
Abstract excerpt
The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where interactions among genes, gene-environment, and acquired ageing-related organ damage are reduced....
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