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Article

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.

Developmental biology - 15 Jul 2004

Dravis Christopher, Yokoyama Nobuhiko, Chumley Michael J, Cowan Chad A, Silvany Robert E, Shay Jennifer, Baker Linda A, Henkemeyer Mark

Abstract excerpt

Incomplete urethral tubularization (hypospadias) and anorectal abnormalities are two common and poorly understood birth defects that affect the extreme caudal midline of the human embryo. We now show that cell surface molecules essential for proper axon pathfinding in the developing nervous system, namely ephrin-B2 and the ephrin receptors EphB2 and EphB3, also play major roles in cell adhesion events that...

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Identifiers

PMID: 15223334
DOI: 10.1016/j.ydbio.2004.03.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.PMID 15223334Read ↗

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