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Article

Urorectal septum malformation sequence: Insights into pathogenesis

2 Nov 2002

Abstract excerpt

We characterize the urorectal septum malformation sequence (URSMS) in discordant fetal lambs and relate it to the human syndromes with which URSMS is associated. We found abnormal external genitalia, imperforate anus, and fistulous connections between the rectum, bladder, and vagina. Discordance among the dizygous twins eliminated teratogens as a likely etiologic factor. We summarize the relevant literature and...

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PMID: 12420289
DOI: 10.1002/ar.10180

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