Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down‐regulated in gastric carcinoma, and shows high evolutionary conservation

21 Jun 2004

Abstract excerpt

Through previous large-scale gene expression profiling we identified a transcript that was abundant in normal stomach and down-regulated in gastric cancer. Genes expressed at similar levels included gastrin, MUC5 and pS2, which are important in gastric function. We aimed to characterise this candidate, gastrokine 1 (GKN1), at mRNA, DNA, protein and tissue levels. The gene was studied in human, mouse, rat and cow,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Helicobacter pylori-related gastroenterology studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-κB Signaling Pathways

Source

Identifiers

PMID: 15221938
DOI: 10.1002/path.1583

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down‐regulated in gastric carcinoma, and shows high evolutionary conservationPMID 15221938Read ↗

A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.Semantic proximity Read ↗

Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor rolesSemantic proximity Read ↗

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progressionSemantic proximity Read ↗

Up-regulation of CLDN1 in gastric cancer is correlated with reduced survivalSemantic proximity Read ↗

Decreased Expression of Gastrokine 1 and the Trefoil Factor Interacting Protein TFIZ1/GKN2 in Gastric Cancer: Influence of Tumor Histology and Relationship to PrognosisSemantic proximity Read ↗

Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3.Semantic proximity Read ↗

Gastrokine 1 Expression in the Human Gastric Mucosa Is Closely Associated with the Degree of Gastritis and DNA MethylationSemantic proximity Read ↗

Identification and validation of genes involved in gastric tumorigenesisSemantic proximity Read ↗

A functional and transcriptomic analysis of NET1 bioactivity in gastric cancerSemantic proximity Read ↗

GKN1–miR-185–DNMT1 Axis Suppresses Gastric Carcinogenesis through Regulation of Epigenetic Alteration and Cell CycleSemantic proximity Read ↗

Endocrine tumours of the gastrointestinal tract: aetiology, molecular pathogenesis and genetics.Semantic proximity Read ↗

CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.