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Article

Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3.

Physiological genomics - 1 Aug 2013

Geahlen Jessica H, Lapid Carlo, Thorell Kaisa, Nikolskiy Igor, Huh Won Jae, Oates Edward L, Lennerz Jochen K M, Tian Xiaolin, Weis Victoria G, Khurana Shradha S, Lundin Samuel B, Templeton Alan R, Mills Jason C

Abstract excerpt

In a screen for genes expressed specifically in gastric mucous neck cells, we identified GKN3, the recently discovered third member of the gastrokine family. We present confirmatory mouse data and novel porcine data showing that mouse GKN3 expression is confined to mucous cells of the corpus neck and antrum base and is prominently expressed in metaplastic lesions. GKN3 was proposed originally to be expressed in...

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Identifiers

PMID: 23715263
DOI: 10.1152/physiolgenomics.00169.2012
PMCID: PMC3742967

Genes

GKN1
GKN2

Provenance

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