Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GKN1–miR-185–DNMT1 Axis Suppresses Gastric Carcinogenesis through Regulation of Epigenetic Alteration and Cell Cycle

11 Jul 2013

Abstract excerpt

PURPOSE: Gastrokine 1 (GKN1) functions to protect the gastric antral mucosa and promotes healing by facilitating restoration and proliferation after injury. GKN1 is downregulated in Helicobacter pylori-infected gastric epithelial cells and loss of GKN1 expression is closely associated with gastric carcinogenesis, but underlying mechanisms of the tumor-suppressing effects of GKN1 remain largely unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to Histone Deacetylase Inhibitors Research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23846337
DOI: 10.1158/1078-0432.ccr-12-3675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GKN1–miR-185–DNMT1 Axis Suppresses Gastric Carcinogenesis through Regulation of Epigenetic Alteration and Cell CyclePMID 23846337Read ↗

Gastrokine 1 Expression in the Human Gastric Mucosa Is Closely Associated with the Degree of Gastritis and DNA MethylationSemantic proximity Read ↗

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progressionSemantic proximity Read ↗

NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancerSemantic proximity Read ↗

lncRNA DLEU2 promotes gastric cancer progression through ETS2 via targeting miR-30a-5pSemantic proximity Read ↗

The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathwaySemantic proximity Read ↗

LINC01089 is a tumor-suppressive lncRNA in gastric cancer and it regulates miR-27a-3p/TET1 axisSemantic proximity Read ↗

A Novel Tumor Suppressor Gene, TMEM171, Inhibits the Development of Gastric Cancer by Dephosphorylating IKBα and Inactivating the NF-kB Signaling PathwaySemantic proximity Read ↗

PKMYT1 Promotes Gastric Cancer Cell Proliferation and Apoptosis ResistanceSemantic proximity Read ↗

Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down‐regulated in gastric carcinoma, and shows high evolutionary conservationSemantic proximity Read ↗

RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathwaySemantic proximity Read ↗

MicroRNA-200b reduced ZEB1 to inhibit cell proliferation and migration in human gastric cancerSemantic proximity Read ↗

Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor rolesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.