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Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor roles

17 Nov 2012

Abstract excerpt

During the past decade, a new family of stomach-specific proteins has been recognized. Known as "gastrokines" (GKNs), these secreted proteins are products of gastric mucus-producing cell lineages. GKNs are highly conserved in physical structure, and emerging data point to convergent functions in the modulation of gastric mucosal homeostasis and inflammation. While GKNs are highly prevalent in the normal stomach,...

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PMID: 23154977
DOI: 10.1152/ajpgi.00374.2012

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