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Article

A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.

Gastroenterology - 1 May 2010

Menheniott Trevelyan R, Peterson Anthony J, O'Connor Louise, Lee Kai Syin, Kalantzis Anastasia, Kondova Ivanela, Bontrop Ronald E, Bell Katrina M, Giraud Andrew S

Abstract excerpt

BACKGROUND & AIMS: Gastrokines are stomach mucus cell-secreted proteins; 2 gastrokines are known, GKN1 and GKN2. Gastrokine expression is lost in gastric cancer, indicating a possible function in tumor suppression. We have identified a third gastrokine gene in mammals. METHODS: Gkn3 was character...

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Source

Identifiers

PMID: 20138039
DOI: 10.1053/j.gastro.2010.01.050

Genes

GKN1
GKN2
TFF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20138039-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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