Article
Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma.
Human mutation - 1 Jul 2004
Wang Yun, Kringen Pedro, Kristensen Gunnar B, Holm Ruth, Baekelandt Mark M O, Olivier Magali, Skomedal Hanne, Hainaut Pierre, Tropé Claes G, Abeler Vera M, Nesland Jahn M, Børresen-Dale Anne-Lise, Helland Aslaug
Abstract excerpt
This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G>C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and were significantly associated with grade of differentiation (P=0.001). A tendency towards higher frequency of sequence...
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