Article
Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4(+) T-cell subsets, including stem cell memory T-cells.
Retrovirology - 12 Nov 2014
Cashin Kieran, Paukovics Geza, Jakobsen Martin R, Østergaard Lars, Churchill Melissa J, Gorry Paul R, Flynn Jacqueline K
Abstract excerpt
BACKGROUND: CD4(+) memory T-cells are a major target for infection by HIV-1, whereby latent provirus can establish and endure suppressive antiretroviral therapies. Although HIV-1 subtype C strains (C-HIV) account for the majority of HIV-1 infections worldwide, the susceptibility of CD4(+) memory T-cells to infection by CCR5- (R5) and CXCR4-using (X4) C-HIV is unknown. Here, we quantified the susceptibility of...
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