Article
HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro.
AIDS (London, England) - 2 Jan 2008
Moncunill Gemma, Armand-Ugón Mercedes, Pauls Eduardo, Clotet Bonaventura, Esté José A
Abstract excerpt
BACKGROUND: HIV-1 coreceptor switch from CCR5 to CXCR4 is associated with disease progression and AIDS. Selection of resistant HIV-1 to CCR5 agents in cell culture has often occurred in the absence of coreceptor switch. With CCR5 antagonists currently in clinical trials, their impact on coreceptor use is still in doubt. METHODS: Six R5 HIV-1 strains were passaged in lymphoid cells expressing high CXCR4 and low...
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