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Article

Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma.

Journal of clinical pathology - 1 Jul 2004

Morris M R, Maina E, Morgan N V, Gentle D, Astuti D, Moch H, Kishida T, Yao M, Schraml P, Richards F M, Latif F, Maher E R

Abstract excerpt

BACKGROUND: Overexpression of the hypoxia inducible factor 1 (HIF-1) and HIF-2 transcription factors and the consequent upregulation of hypoxia inducible mRNAs is a feature of many human cancers and may be unrelated to tissue hypoxia. Thus, the VHL (von Hippel-Lindau) tumour suppressor gene (TSG) regulates HIF-1 and HIF-2 expression in normoxia by targeting the alpha subunits for ubiquitination and proteolysis....

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Source

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Identifiers

PMID: 15220362
DOI: 10.1136/jcp.2003.011767
PMCID: PMC1770369

Genes

VHL
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma.PMID 15220362Read ↗

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Role of the<i>VHL</i>(von Hippel–Lindau) gene in renal cancer: a multifunctional tumour suppressorSemantic proximity Read ↗

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