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Article

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Anticancer research - 1 Nov 2009

Morris Mark R, Hughes David J, Tian Ya-Min, Ricketts Christopher J, Lau Kah Weng, Gentle Dean, Shuib Salwati, Serrano-Fernandez Pablo, Lubinski Jan, Wiesener Michael S, Pugh Christopher W, Latif Farida, Ratcliffe Peter J, Maher Eamonn R

Abstract excerpt

BACKGROUND: Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1alpha and -2alpha is a critical event in the pathogenesis of most clear cell renal cell carcinomas (RCC). HIF-1alpha and HIF-2alpha share sign...

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Source

Identifiers

PMID: 20032376

Genes

VHL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20032376-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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