Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.

PloS one - 24 Jun 2009

Ricketts Christopher, Zeegers Maurice P, Lubinski Jan, Maher Eamonn R

Abstract excerpt

BACKGROUND: The investigation of rare familial forms of kidney cancer has provided important insights into the biology of sporadic renal cell carcinoma (RCC). In particular, the identification of the von Hippel Lindau (VHL) familial cancer syndrome gene (VHL) provided the basis for the discovery that VHL is somatically inactivated in most sporadic clear cell RCC. Many cases of familial RCC do not have mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase A
Share to Aurora Kinases
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Insulin-Like Growth Factor Binding Proteins

Share to Matrix Metalloproteinase 1

Share to Matrix Metalloproteinase 3

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19551141
DOI: 10.1371/journal.pone.0006037
PMCID: PMC2696041

Genes

VHL
MMP1
MMP3
CDH1
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.PMID 19551141Read ↗

Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.Semantic proximity Read ↗

VHL protein alterations in sporadic renal cell carcinoma.Semantic proximity Read ↗

Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC.Semantic proximity Read ↗

Determination of vhl gene mutations in sporadic renal cell carcinoma.Semantic proximity Read ↗

Risk factors, genetic predisposition and mutations in the VHL gene in sporadic renal cell carcinoma: The Netherlands Cohort Study.Semantic proximity Read ↗

Does the VHL polymorphisms rs779805 and rs1642742 affect renal cell carcinoma susceptibility, prognosis and survival in Central European population?Semantic proximity Read ↗

VHL gene alterations in renal cell carcinoma patients: novel hotspot or founder mutations and linkage disequilibrium.Semantic proximity Read ↗

Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis.Semantic proximity Read ↗

Mutations of the VHL tumour suppressor gene in renal carcinoma.Semantic proximity Read ↗

Characterizing and predicting ccRCC-causing missense mutations in Von Hippel-Lindau diseaseSemantic proximity Read ↗

Unique molecular alteration patterns in von Hippel-Lindau (VHL) gene in a cohort of sporadic renal cell carcinoma patients from Pakistan.Semantic proximity Read ↗

Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL,MET, and CUL2candidate genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.