Article
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.
Diabetes - 1 May 2003
Sesti Giorgio, Cardellini Marina, Marini Maria Adelaide, Frontoni Simona, D'Adamo Monica, Del Guerra Silvia, Lauro Davide, De Nicolais Pierluigi, Sbraccia Paolo, Del Prato Stefano, Gambardella Sergio, Federici Massimo, Marchetti Piero, Lauro Renato
Abstract excerpt
It was reported that the common -866G/A polymorphism in the promoter of the human uncoupling protein-2 (UCP2) gene, which enhances its trascriptional activity, is associated with increased mRNA levels in human adipocytes and reduced risk of obesity. Studies in knockout mice and beta-cells indicate that UCP2 may play a role in beta-cell function. In this study, we addressed the question of whether the common...
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