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Article

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.

The Journal of clinical endocrinology and metabolism - 1 Feb 2005

Bulotta Angela, Ludovico Ornella, Coco Angelo, Di Paola Rosa, Quattrone Alessandro, Carella Massimo, Pellegrini Fabio, Prudente Sabrina, Trischitta Vincenzo

Abstract excerpt

Uncoupling protein-2 (UCP2) regulates insulin secretion and may play an important role in linking obesity to type 2 diabetes (T2D). Previous studies of the role of the UCP2 promoter -866G/A single nucleotide polymorphisms (SNP) in T2D have given opposite results. We tested the distribution of the -866G/A SNP in 746 T2D patients and 327 healthy unrelated Caucasians from Italy. We also tested for an effect of the...

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Identifiers

PMID: 15562023
DOI: 10.1210/jc.2004-1072

Genes

UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.PMID 15562023Read ↗

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

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A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.Semantic proximity Read ↗

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.Semantic proximity Read ↗

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.Semantic proximity Read ↗

The common -866G/A polymorphism of the UCP2 gene in healthy Iranians compared with world populations.Semantic proximity Read ↗

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Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism -866 G/A in the promoter region is associated with Type 2 Diabetes Mellitus among Kashmiri population of Northern IndiaSemantic proximity Read ↗

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