Pathology of Gastrointestinal Stromal Tumors

Abstract excerpt

Gastrointestinal stromal tumor (GIST) is a well recognized and relatively well understood soft tissue tumor. Early events in GIST development are activating mutations in KIT or PDGFRA, which occur in most GISTs and encode for mutated tyrosine receptor kinases that are therapeutic targets for tyrosine kinase inhibitors, including imatinib and sunitinib. A small minority of GISTs possessing neither KIT nor PDGFRA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gastrointestinal disorders and treatments
• Share to Gastrointestinal Tumor Research and Treatment
• Share to Sarcoma Diagnosis and Treatment