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Article

RUNX genes find a niche in stem cell biology

26 Jun 2009

Abstract excerpt

The RUNX family of transcriptional regulators are well conserved throughout the animal kingdom, from the simple nematode worm Caenorhabditis elegans to vertebrates. Interest in the RUNX genes emerged principally as a result of the finding that chromosomal translocations disrupting RUNX protein function are observed in a large number of patients suffering with acute myeloid leukemia (AML). In the 20 years that...

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PMID: 19562739
DOI: 10.1002/jcb.22249

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