Article
Epigenetic modifiers exert renal toxicity through induction of p66shc.
Anticancer research - 1 Oct 2011
Arany Istvan, Clark Jeb S, Ember Istvan, Juncos Luis A
Abstract excerpt
BACKGROUND/AIMS: Trichostatin A (TSA) and 5-azacytidine (5AZA) induce reactive oxygen species (ROS)-mediated injury in renal proximal tubule cells. Since TSA and 5AZA are activators of p66shc, we questioned whether p66shc may mediate renal toxicity of TSA- and 5AZA. MATERIALS AND METHODS: Renal proximal tubule cells were treated with either TSA or 5AZA for 24 hours followed by treatment with 200 μM H(2)O(2)....
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