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Article

Epigenetic modifiers exert renal toxicity through induction of p66shc.

Anticancer research - 1 Oct 2011

Arany Istvan, Clark Jeb S, Ember Istvan, Juncos Luis A

Abstract excerpt

BACKGROUND/AIMS: Trichostatin A (TSA) and 5-azacytidine (5AZA) induce reactive oxygen species (ROS)-mediated injury in renal proximal tubule cells. Since TSA and 5AZA are activators of p66shc, we questioned whether p66shc may mediate renal toxicity of TSA- and 5AZA. MATERIALS AND METHODS: Renal p...

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PMID: 21965735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21965735-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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